Endocrine Abstracts

Vitamin D deficiency has become a worldwide problem, although vitamin D deficiency had associated with increased insulin resistance, obesity and HbA1c in patients with T2D.It is uncertain whether vitamin D deficiency causes diabetes or its due to confounding. The active metabolite 1α,25-dihydroxyvitamin D3 may affect the receptors of pancreatic β-cells and hence affect insulin secretion, also it may have impact on insulin sensitivity.<p cla...

Back ground and objectives: Relation between thyroid function with respect to insulin resistance has been a field that is rich and captivating for research and further examination. Few studies have suggested that metformin, the first-line in diabetes management, may lower thyroid-stimu-lating hormone (TSH). Owing to Paucity of studies regarding the effect of metformin on TSH in hypothyroidism patients, this study compares the effect of metformin on TSH and BMI in Egyptian na&#...

Background: Visceral fat-derived protein named visfatin was discovered in 2005. Visfatin may improve glucose tolerance, and its plasma levels correlate strongly with the amount of visceral adipose tissue in humans. Visfatin has insulin-like metabolic effects on glucose metabolism but has a distinct binding site on insulin receptors. These findings triggered great interest for many researchers to explore the mechanism(s) of regulation of visfatin expression, and the possible re...